Miranda is a portable application,
Such "portable" applications runs on PE easly, mostly by only adding missing files, mostly some dll .
Skype probably more complicated,
As I already wrote,
you need to work on it, spend time, to figure out, probably using Process Monitor
That is the reason we include Process Monitor plugin at all projects

So end user have the power tool to work on such tasks easly with an available plugin for Process Monitor

If you succeed, let all others know your findings

