For info:
I tested with 8.1 OS x86/x64, the remote registry HKLM, HKCU is well mounted here.
I have the default settings: Runscanner.exe /t 0 /sd /ac /m+ /y regedit.exe.
in 64 bit PE regedit.exe 32-bit is called.
Is it fine to use Remote Regedit to edit an offline 64 bit OS registry from a 32 bit PE ?.
Whatever the PE or host architecture, remote regedit seems to work fine without concern to edit it.