I am getting the error when I attempt to build my PE using the Dec. '20 XPE package and Win10 2004:
Any idea what it means?
Well, the tools are there for me, using that same setup, so the most likely cause is that the files are being deleted by your A/V either during the download of the distribution file, it's extraction to the base folder, or the start of running the project.
If you submitted a log it might show what's happening