There have been Several Reports of Rufus failing to Boot a Legacy System when Using NTFS Partition Format
UEFI System do not seem to be effected.... And you only reported "will NOT boot on every machine"
Insert Win10XPE Media
Open Command Prompt (admin) > Type
DiskPart
List volume
Select volume X (where X is the USB volume drive number)
List Partition
Post a Screenshot of command windows
To Fix - Do Not use Rufus...
The following Setup assumes a USB Flash Drive with enough space to create a 8GB Fat32 Partition & the Remainder of space as NTFS Partition
DiskPart
List volume
Select volume X (where X is the USB drive letter.)
Clean
Create partition primary size=8192
Format FS=FAT32 quick
Active
Create partition primary
Format FS=NTFS quick
Exit
Use Copy/Paste to copy the contents of Mounted Win10XPE*.iso to the Fat32 Partition
But use what ever Project works best for you.... As the Choice is Yours